Drenching downpours and locally gusty thunderstorms will erupt over parts of the southern and central Plains through Thursday.
"Into Wednesday night, the heaviest rain will extend from central Kansas to northern and central Oklahoma, the northern Texas Panhandle and adjacent New Mexico," according to AccuWeather Lead Storm Warning Meteorologist Eddie Walker.
The commute along Interstate 35 between Oklahoma City and Wichita, Kansas, will be slow at times due to excess water on the road and poor visibility. Similar conditions are likely along portions of I-40 in Oklahoma and Texas and I-135 in Kansas.
In terms of severe weather, a few storms can become severe at the local level in parts of northwestern Texas, Oklahoma and Kansas on Friday afternoon and evening.
People should be prepared for travel delays around Topeka, Kansas, Kansas City, Missouri, and Des Moines, Iowa, or essentially along I-35 in this zone.
The rainfall will impact agriculture in the region.
"On one hand, the rain will slow the corn harvest in some areas and the planting of winter wheat in others," according to AccuWeather Senior Meteorologist Jason Nicholls.
The area being affected by the downpours has received between 10 and 80 percent of normal rainfall since Sept. 1.
As cooler air advances to the east, it will help to pull up a tropical system currently brewing near Central America.