The Laurens County Water and Sewer Commission (LCWSC) said the city of Clinton issued an advisory at 11:30 p.m. Wednesday, Dec. 12.
The LCWSC said the city is a primary source of water distributed in its system and has extended the advisory.
Customers on numerous roads from Highway 49 near I-385, along stretches of Highways 72 and 76, are among those impacted.
LCWSC posted a map on its website showing an area that included roads in Laurens, Cross Hill, Mountville and Waterloo.
Click or tap here for a list of roads.
Customers in the affected area are advised to boil water for at least one minute before drinking or cooking.
This includes water that will be frozen into ice.
The notice remains in effect until further notice.
Anyone with questions is asked to call 864-682-3250.